![]() Sex differences in clinical and hemodynamic variables by age group among adults with systolic blood pressure=140 mmHg or diastolic blood pressure=90 mmHg. (PDF) S3 Fig Systemic vascular resistance and systemic vascular resistance index density plots overlap between women and men with systolic blood pressure=140 mmHg or diastolic blood pressure=90 mmHg, by age category. (PDF) S2 Fig Cardiac output and cardiac index density plots overlap between women and men with systolic blood pressure=140 mmHg or diastolic blood pressure=90 mmHg, by age category. Supporting information S1 Fig Median cardiac output, cardiac index, systemic vascular resistance, and systemic vascular resistance index by age among women and men with systolic blood pressure=140 mmHg or diastolic blood pressure=90 mmHg. Accordingly, the authors used data from tens of thousands of individuals with elevated blood pressure from an outpatient setting in China to evaluate the overall patterns of sex differences in hemodynamic variables and to determine how these sex hemodynamic differences may vary with age. Assessing the sex-specific differences in hemodynamic profiles across age groups can provide a better understanding on whether there are substantial hemodynamic differences by sex that could be used to guide therapy. For the analysis the authors used the average age of menopause in China and the results were consistent with this hemodynamic shift among women around age 50 years.Ĭonsidering that tailoring antihypertensive treatment based on individuals` hemodynamic profile may be associated with better blood pressure control, these sex differences on hemodynamic phenotypes could help to identify more personalized therapeutic approaches. Considering the well-known body composition differences between men and women the authors analyzed the hypertension phenotype using the body surface area adjusted values (CI and SVRI) and stratified by age increasing the comparability of these variables between sexes consistent with the previous studies. how: Given that the de-identified data were provided by a third party the authors did not need to collect consent for participation.The authors investigated sex differences in hemodynamic variables, mainly CI and SVRI, among adults presenting with elevated blood pressure. Ethics statement This project received an exemption from review from the Institutional Review Board at Yale School of Medicine and at Shanghai Jiao Tong University College of Biotechnology as the authors used de-identified data provided by the iKang Health group. what: Most of the studies addressing these underlying hemodynamic sex differences have had small samples or focused exclusively on younger individuals, which limits the generalizability of their findings to a broader population that includes the elderly, among whom the hypertension burden is greater.who: Cu00e9sar Caraballo and colleagues from the Editor:, University of Zurichthe Ministry of Science and Technology of China have published the research: Hemodynamic differences between women and men with elevated blood pressure in China: A non-invasive assessment of 45,082 adults using impedance cardiography, in the Journal: PLOS ONE of May/19,/2021. ![]()
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